The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.

Fung, S.Y.; Tan, N.H.; Liew, S.H.; Sim, S.M.; Aguiyi, J.C. (2009) The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats. Tropical biomedicine, 26 (1). pp. 80-4. ISSN 0127-5720

Full text not available from this repository.

Abstract

Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.

Item Type: Article
Creators:
  1. Fung, S.Y.
  2. Tan, N.H.
  3. Liew, S.H.
  4. Sim, S.M.
  5. Aguiyi, J.C.
Journal or Publication Title: Tropical biomedicine
Additional Information: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50602 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Mucuna pruriens (Velvet beans)
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 30 Apr 2011 09:41
Last Modified: 30 Apr 2011 09:41
URI: http://eprints.um.edu.my/id/eprint/1137

Actions (For repository staff only: Login required)

View Item