MicroRNA pathways: An emerging role in identification of therapeutic strategies

Vijayarathna, S. and Oon, C.E. and Jothy, S.L. and Chen, Y. and Kanwar, J.R. and Sasidharan, S. (2014) MicroRNA pathways: An emerging role in identification of therapeutic strategies. Current Gene Therapy, 14 (2). pp. 112-120. ISSN 1566-5232

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Abstract

For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.

Item Type: Article
Uncontrolled Keywords: Cells; Spectrum; Patways; Expression; Biogenesis
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 20 Nov 2014 02:06
Last Modified: 20 Nov 2014 02:06
URI: http://eprints.um.edu.my/id/eprint/11366

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