Kaviarasan, S.; Muniandy, S.; Qvist, R.; Ismail, I.S. (2009) F(2)-isoprostanes as novel biomarkers for type 2 diabetes: a review. Journal of clinical biochemistry and nutrition, 45 (1). pp. 1-8. ISSN 0912-0009
Full text not available from this repository. (Request a copy)Abstract
Oxidative stress (OS) has been implicated as one of the major underlying mechanisms behind many acute and chronic diseases. However, the measurement of free radicals or their end products is complicated. Isoprostanes, derived from the non-enzymatic peroxidation of arachidonic acid are now considered to be reliable biomarkers of oxidant stress in the human body. Isoprostanes are involved in many of the human diseases such as type 2 diabetes. In type 2 diabetes elevated levels of F(2)-Isoprostanes (F(2)-IsoPs) have been observed. The measurement of bioactive F(2)-IsoPs levels offers a unique noninvasive analytical tool to study the role of free radicals in physiology, oxidative stress-related diseases, and acute or chronic inflammatory conditions. Measurement of oxidative stress by various other methods lacks specificity and sensitivity. This review aims to shed light on the implemention of F(2)-IsoPs measurement as a gold-standard biomarker of oxidative stress in type 2 diabetics.
| Item Type: | Article |
|---|---|
| Creators: | |
| Journal or Publication Title: | Journal of clinical biochemistry and nutrition |
| Additional Information: | Department of Medicine, University of Malaya Medical Center, University of Malaya, 50603 Kuala Lumpur, Malaysia |
| Uncontrolled Keywords: | oxidative stress; lipid peroxidation; isoprostanes; type 2 diabetes |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 29 Apr 2011 11:49 |
| Last Modified: | 29 Apr 2011 11:49 |
| URI: | http://eprints.um.edu.my/id/eprint/1127 |
Actions (login required)
| View Item |
