Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems

Ahmad, N. and Ramsch, R. and Llinas, M. and Solans, C. and Hashim, R. and Tajuddin, H.A. (2014) Formation of Nonionic Branched-Chain Glycolipids Nano-Emulsion for drug delivery systems. In: Seoul International Conference on Applied Science and Engineering (SICASE), 29-31 Aug 2014, Seoul, South Korea. (Submitted)

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Abstract

The effect of incorporating new nonionic glyco lipid surfactants on the properties of a model water/nonionic surfactant/oil nano-emulsion system was investigated using branched-chain alkyl glycosides : 2-hexyldecyl-p(la)-D -glucoside (2-HDG) and 2-hexyldecyl-p(la)-D -maltoside (2-HDM), whose structures are closely related to glycero-glycolipids. Both 2-HDG and 2-HDM have an identical hydrophobic chain (C 16), but the former consists a monosaccharide glucose head group, in contrast to the latter which has a disaccharide maltose unit. Consequently, their hydrophilic-lipophilic balance (HLB) is different. The results obtained have shown that these branched-ehain alkyl glycosides affect differently the stability of the nano-emu lsions. Compared to the model nanoemulsion, the presence of 2-HDG reduces the oil droplet size, whereas 2-HDM modify the properties of the model nano-emulsion system in terms of its droplet size and storage time stability at high temperature. These nano-emulsions have been proven capable of encapsulating ketoprofen, showing a fast release of almost 100% in 24 hours . Thus, both branched-chain alkyl glycosides are suitable as nano-cmulsion stabilizing agents and as drug delivery systems in the future .

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Branched-Chain Alkyl Glycoside, onionic Surfactant, ano-Emulsion, Drug Delivery, Ketoprofen
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Mr. Mohd Samsul Ismail
Date Deposited: 16 Oct 2014 01:11
Last Modified: 16 Oct 2014 07:29
URI: http://eprints.um.edu.my/id/eprint/11093

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