Metabolic syndrome and cardiovascular risk among patients with schizophrenia receiving antipsychotics in Malaysia

Said, M.A.; Sulaiman, A.H.; Habil, M.H.; Das, S.; Abu Bakar, A.K.; Yusoff, R.M.; Loo, T.H.; Abu Bakar, S. (2012) Metabolic syndrome and cardiovascular risk among patients with schizophrenia receiving antipsychotics in Malaysia. Singapore Medical Journal, 53 (12). pp. 801-807. ISSN 0037-5675

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    Abstract

    INTRODUCTION This study aimed to determine the prevalence of metabolic syndrome and risk of coronary heart disease (CHD) in patients with schizophrenia receiving antipsychotics in Malaysia. METHODS This cross-sectional study, conducted at multiple centres, involved 270 patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV-TR diagnostic criteria for schizophrenia, were on antipsychotic medications for at least one year, and were screened for metabolic syndrome. Patients receiving mood stabilisers were excluded. Metabolic syndrome was defined according to the National Cholesterol Education Program ATP III criteria modified for Asian waist circumference. Risk for cardiovascular disease was assessed by using Framingham function (all ten-year CHD events). RESULTS The prevalence of metabolic syndrome was 46.7 (126/270). Among all the antipsychotics used, atypical antipsychotics (monotherapy) were most commonly used in both the metabolic and non-metabolic syndrome groups (50.8 vs. 58.3). The ten-year risk for CHD was significantly higher in patients with metabolic syndrome. The proportion of patients with high/very high risk for CHD (Framingham >= 10) was greater in patients with metabolic syndrome than in those with non-metabolic syndrome (31.5 vs. 11.0, odds ratio 3.9, 95 confidence interval 2.0-7.6; p < 0.001). The mean body mass index was higher in patients with metabolic syndrome than in those without (29.4 +/- 5.1 kg/m(2) vs. 25.0 +/- 5.6 kg/m(2); p < 0.001). CONCLUSION Patients with schizophrenia receiving antipsychotics in Malaysia have a very high incidence of metabolic syndrome and increased cardiovascular risk. Urgent interventions are needed to combat these problems in patients.

    Item Type: Article
    Creators:
    1. Said, M.A.
    2. Sulaiman, A.H.(Department of Psychological Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    3. Habil, M.H.(Department of Psychological Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    4. Das, S.
    5. Abu Bakar, A.K.
    6. Yusoff, R.M.
    7. Loo, T.H.
    8. Abu Bakar, S.(Department of Medical Microbiology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, Malaysia)
    Journal or Publication Title: Singapore Medical Journal
    Uncontrolled Keywords: Body mass index, cardiovascular risk, metabolic syndrome, prevalence, schizophrenia
    Subjects: B Philosophy. Psychology. Religion > BF Psychology
    R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 05 Aug 2014 10:31
    Last Modified: 05 Aug 2014 10:31
    URI: http://eprints.um.edu.my/id/eprint/10977

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