Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone

Roffeei, S.N. and Reynolds, G.P. and Zainal, N.Z. and Said, M.A. and Hatim, A. and Aida, S.A. and Mohamed, Z. (2014) Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone. Human Psychopharmacology-Clinical and Experimental, 29 (1). pp. 38-45. ISSN 0885-6222

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/hup.236...

Abstract

ObjectivesVarious genetic polymorphisms have been reported to be associated with antipsychotic-induced weight gain. In this study, we aimed to determine whether risk polymorphisms in 12 candidate genes are associated with reduction in body mass index (BMI) of patients following switching of antipsychotics to aripiprazole or ziprasidone. MethodsWe recruited 115 schizophrenia patients with metabolic abnormalities and who have been on at least 1year treatment with other antipsychotics; they were then switched to either aripiprazole or ziprasidone. They were genotyped, and their BMI monitored for 6months. ResultsSignificant associations with reduction in BMI at 6months following switching were found in two of these genes: with rs1800544 of the ADRA2A gene (CC+CG -0.321.41kg/m(2) vs GG -1.04 +/- 1.63kg/m(2), p=0.013) and with rs1801131 of the MTHFR gene (AA -0.36 +/- 1.53 vs AC+CC -1.07 +/- 1.53, p=0.015). ConclusionThe study data indicated that carriage of the ADRA2A rs1800544 GG genotype and the MTHFR rs1801131 C allele are associated with BMI reduction in this population following switching of antipsychotics to aripiprazole and ziprasidone. Copyright (c) 2013 John Wiley & Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: Schizophrenia;antipsychotic-induced weight gain;-1291C/G adrenergic receptor;1298A/C methylenetetrahydrofolate reductase;aripiprazole;ziprasidone
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 18 Jul 2014 00:20
Last Modified: 18 Jul 2014 00:20
URI: http://eprints.um.edu.my/id/eprint/10964

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