Factor V inhibitor in neonatal intracranial hemorrhage secondary to severe congenital factor V deficiency

Lee, Way Seah and Chong, L.A. and Begum, S. and Abdullah, W.A. and Koh, M.T. and Lim, E.J. (2001) Factor V inhibitor in neonatal intracranial hemorrhage secondary to severe congenital factor V deficiency. Journal of Pediatric Hematology/Oncology, 23 (4). pp. 244-246. ISSN 1077-4114

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Abstract

We report a newborn infant girl, born to consanguine ous parents, with recurrent intracranial hemorrhage secondary to congenital factor V deficiency with factor V inhibitor. Repeated transfusions of fresh-frozen plasma (FFP) and platelet concentrates, administrations of immunosuppressive therapy (prednisolone and cyclophosphamide), and intravenous immunoglobulin failed to normalize the coagulation profiles. Exchange transfusion followed-up by administrations of activated prothrombin complex and transfusions of FFP and platelet concentrates caused a temporary normalization of coagulation profile, enabling an insertion of ventriculoperitoneal (VP) shunt for progressive hydrocephalus. The treatment was complicated by thrombosis of left brachial artery and ischemia of left middle finger. The child finally died from another episode of intracranial hemorrhage 10 days after insertion of the VP shunt.

Item Type: Article
Uncontrolled Keywords: factor V inhibitor; intracranial hemorrhage; congenital factor V; deficiency; newborn infant; concentrate
Subjects: R Medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 14 Jul 2014 00:16
Last Modified: 21 Mar 2019 06:51
URI: http://eprints.um.edu.my/id/eprint/10924

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