Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice

Lee, W.S.; Lum, L.C.; Harun, F. (2003) Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice. The Medical journal of Malaysia, 58 (2). p. 279. ISSN 0300-5283

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    A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant developed Addisonian-like crisis with bradycardia, hypotension, respiratory distress, metabolic acidosis, hypoglycaemia, hyponatraemia, and hyperkalaemia. Blood investigations confirmed congenital hypopituitarism. Hormone replacement therapy with L-thyroxine and cortisone acetate resulted in dissolution of jaundice and the reduction of the liver size.

    Item Type: Article
    1. Lee, W.S.(Department of Paediatrics, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Lum, L.C.
    3. Harun, F.
    Journal or Publication Title: The Medical journal of Malaysia
    Uncontrolled Keywords: Cogenitial hypopituitarism; cholestasic jaundice; addisonian-like crisis
    Subjects: R Medicine
    R Medicine > RJ Pediatrics
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 14 Jul 2014 08:20
    Last Modified: 14 Jul 2014 08:20

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