Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice

Lee, W.S. and Lum, L.C. and Harun, F. (2003) Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice. The Medical Journal of Malaysia, 58 (2). p. 279. ISSN 0300-5283

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Abstract

A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant developed Addisonian-like crisis with bradycardia, hypotension, respiratory distress, metabolic acidosis, hypoglycaemia, hyponatraemia, and hyperkalaemia. Blood investigations confirmed congenital hypopituitarism. Hormone replacement therapy with L-thyroxine and cortisone acetate resulted in dissolution of jaundice and the reduction of the liver size.

Item Type: Article
Uncontrolled Keywords: Cogenitial hypopituitarism; cholestasic jaundice; addisonian-like crisis
Subjects: R Medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 14 Jul 2014 00:20
Last Modified: 26 Oct 2018 02:13
URI: http://eprints.um.edu.my/id/eprint/10921

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