Chatchatee, P. and Lee, Way Seah and Carrilho, E. and Kosuwon, P. and Simakachorn, N. and Yavuz, Y. and Schouten, B. and Logtens-de Graaff, P. and Szajewska, H. (2014) Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children. Journal of Pediatric Gastroenterology and Nutrition, 58 (4). pp. 428-437. ISSN 0277-2116, DOI https://doi.org/10.1097/mpg.0000000000000252.
Full text not available from this repository.Abstract
Objective: The aim of this study was to investigate the effect of growing-up milk (GUM) with added short-chain galacto-oligosaccharides (scGOS)/long-chain fructo-oligosaccharides (lcFOS) (9:1) (Immunofortis) and n-3 long-chain polyunsaturated fatty acids (LCPUFAs) on the occurrence of infections in healthy children attending day care centres. Methods: In a randomised double-blind controlled, parallel, multicountry intervention study, 767 healthy children, ages 11 to 29 months, received GUM with scGOS/lcFOS/LCPUFAs (the active group, n = 388), GUM without scGOS/lcFOS/LCPUFAs (the control group, n = 379), or cow's milk (n = 37) for 52 weeks. The primary outcome measure was the number of episodes of upper respiratory tract infections or gastrointestinal infections based on a combination of subject's illness symptoms reported by the parents during the intervention period. Results: Children in the active group compared with the control group had a decreased risk of developing at least 1 infection (299/388 77% vs 313/379 83%, respectively, relative risk 0.93, 95% confidence interval CI 0.87-1.00; logistic regression P = 0.03). There was a trend toward a reduction (P = 0.07) in the total number of infections in the active group, which was significant when confirmed by one of the investigators (268/388 69% vs 293/379 77%, respectively, relative risk 0.89, 95% CI 0.82-0.97; P = 0.004, post hoc). More infectious episodes were observed in the cow's milk group, when compared with both GUM groups (34/37 92% vs 612/767 80%, respectively, relative risk 1.15, 95% CI 1.04-1.28). Conclusions: This is the first study in children to show a reduced risk of infection following consumption of GUM supplemented with scGOS/lcFOS/n-3 LCPUFAs. The borderline statistical significance justifies a new study to confirm this finding.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Growing-up milk, infection, n-3 LCPUFAs, scGOS/lcFOS, young children |
| Subjects: | R Medicine R Medicine > RJ Pediatrics > Child health. Child health services |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Haslinda Lahuddin |
| Date Deposited: | 14 Jul 2014 00:25 |
| Last Modified: | 21 Mar 2019 06:48 |
| URI: | http://eprints.um.edu.my/id/eprint/10873 |
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