Dengue infection in pregnancy - Prevalence, vertical transmission, and pregnancy outcome

Tan, P.C. and Rajasingam, G. and Devi, S. and Omar, S.Z. (2008) Dengue infection in pregnancy - Prevalence, vertical transmission, and pregnancy outcome. Obstetrics and Gynecology, 111 (5). pp. 1111-1117. ISSN 0029-7844

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Abstract

OBJECTIVE: To estimate prevalence rate of recent dengue infection in parturients, as well as the vertical transmission rate, and to compare pregnancy outcomes among infected women. METHOD: A prospective cohort study was performed. Maternal and paired umbilical cord bloods were taken at delivery. A brief questionnaire on febrile illness and dengue in pregnancy was completed by participants. The samples were sent to a World Health Organization Collaborating Center for Arbovirus Reference and Research. Maternal sera were tested with a dengue-specific immunoglobulin M (IgM) capture test. The paired umbilical cord serum was tested to determine when the maternal sample was positive. Dengue reverse transcriptase polymerase chain reaction (PCR) was performed on all dengue IgM-positive sera. Pregnancy outcome was extracted from delivery records. RESULTS: A total of 2,958 parturients were enrolled, and 2,531 paired maternal-umbilical cord blood samples were available for testing. Dengue-specific IgM was positive in 63 of 2,531 (2.5, 95 confidence interval CI 1.9-3.2%) maternal samples. Only 1 of 64 (1.6%, 95% CI 0.0-9.5%) of the paired umbilical cord sera was IgM-positive. All reverse transcriptase PCR tests were negative. Fifty-six of 63 (88.9%) of dengue IgM-positive women did not report a febrile illness in pregnancy. Apart from a higher mean age in dengue IgM-positive women of 30.6 +/- 5.2 compared with 29.2 +/- 4.9 years (P=.025) compared with dengue IgM-negative women, all other characteristics were similar. Rates of preterm birth, mode of delivery, postpartum hemorrhage, low birth weight, and neonatal outcomes were not different. CONCLUSION: Recent dengue infection was demonstrated in 2.5% of parturients, with a vertical transmission rate of 1.6%. Pregnancy outcome of recently infected women was not different.

Item Type: Article
Uncontrolled Keywords: Research Report; Cohort Analysis; Prevalence; Dengue; Mother-to-Child Transmission; Pregnancy Outcomes; Infections; Developing Countries; Family Relationships; Family Characteristics
Subjects: R Medicine
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 14 Jul 2014 00:37
Last Modified: 14 Jul 2014 00:37
URI: http://eprints.um.edu.my/id/eprint/10860

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