Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia

Baddam, Ramani and Kumar, Narender and Thong, Kwai Lin and Ngoi, Soo Tein and Teh, Cindy Shuan Ju and Yap, Kien Pong and Chai, Lay Ching and Avasthi, Tiruvayipati Suma and Ahmed, Niyaz (2012) Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia. Journal of Bacteriology, 194 (13). pp. 3565-3566. ISSN 0021-9193

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Official URL: https://doi.org/10.1128/JB.00581-12

Abstract

Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of Salmonella Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent Salmonella Typhi strain BL196/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere.

Item Type: Article
Additional Information: Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Salmonella enterica serovar Typhi; typhoid fever; Kelantan; Malaysia
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QR Microbiology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Prof. Dr Kwai Lin Thong
Date Deposited: 14 Oct 2014 03:19
Last Modified: 03 Dec 2019 04:39
URI: http://eprints.um.edu.my/id/eprint/10642

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