Hajrezaie, M. and Paydar, M. and Moghadamtousi, S.Z. and Hassandarvish, P. and Gwaram, N.S. and Zahedifard, M. and Rouhollah, E. and Karimian, H. and Looi, C.Y. and Ali, H.M. and Majid, N.A. and Abdulla, M.A. (2014) A schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway. Scientific World Journal.
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Abstract
Metal-based drugs with extensive clinical applications hold great promise for the development of cancer chemotherapeutic agents. In the last few decades, Schiff bases and their complexes have become well known for their extensive biological potential. In the present study, we examined the antiproliferative effect of a copper (II) complex on HT-29 colon cancer cells. The Cu(BrHAP)2 Schiff base compound demonstrated a potent tiproliferative effect in HT-29 cells, with an IC50 value of 2.87
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Biomedical Science, Faculty of Medicine, University of Malaya |
| Uncontrolled Keywords: | Schiff Base-Derived Copper (II) Complex; Potent Inducer of Apoptosis; Colon Cancer Cells; Intrinsic Pathway |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Jamilah Salleh |
| Date Deposited: | 11 Nov 2014 04:24 |
| Last Modified: | 11 Nov 2014 04:24 |
| URI: | http://eprints.um.edu.my/id/eprint/10529 |
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