Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations

Choong, S.S. and Latiff, Z.A. and Mohamed, M. and Lim, L.L.W. and Chen, K.S. and Vengidasan, L. and Razali, H. and Abdul Rahman, E.J. and Ariffin, H. (2012) Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations. Clinical Genetics. ISSN 0009-9163

[img] PDF
00000727_80283.pdf - Published Version
Restricted to Registered users only

Download (643kB)

Abstract

Li-Fraumeni syndrome (LFS) is a highly penetrant, autosomal dominant disorder where affected individuals carry a 50% risk of developing cancer before 30 years of age. It is most commonly associated with mutations in the tumour suppressor gene, TP53. Adrenocortical carcinoma (ACC) is a very rare paediatric cancer, and up to 80% of affected children are found to carry germline TP53 mutations. Hence, we propose using childhood ACC incidence as selection criteria for referral for TP53 mutation testing, independent of familial cancer history. Under the auspices of the Malaysian Society of Paediatric Haematology–Oncology, four eligible children diagnosed with ACC over a 30-month study period were referred for mutation testing. Three had a germline TP53 mutation. Subsequent TP53 testing in relatives showed two inherited mutations and one de novo mutation. These findings strongly support paediatric ACC as a useful sentinel cancer for initiating a germline TP53 /LFS detection programme, particularly in countries where the lack of structured oncogenetic practice precludes the identification of families with LFS features.

Item Type: Article
Uncontrolled Keywords: Childhood adrenocortical carcinoma; germline TP53 mutations
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Jamilah Salleh
Date Deposited: 14 Oct 2014 02:31
Last Modified: 14 Oct 2014 02:31
URI: http://eprints.um.edu.my/id/eprint/10499

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year