Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

Awang, Khalijah and Mukhtar, Mat Ropi and Osman, Norfaizah and Hazni, Hazrina and Qureshi, Ahmad Kaleem and Hadi, A. Hamid A. and Zaima, Kazuma and Morita, Hiroshi and Litaudon, Marc (2012) Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules, 17. pp. 267-274. ISSN 1420-3049

[img]
Preview
PDF
Neonaucline,_a_new_indole_alkaloid_from_the_leaves_of_Ochreinauclea_maingayii_(Hook._f.)_Ridsd._(Rubiaceae).pdf - Published Version

Download (120kB)

Abstract

A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10-5 M.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Ochreinauclea maingayii; Neonaucline; Nauledine; Cadamine; Rubiaceae; Alkaloid.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 14 Oct 2014 02:36
Last Modified: 24 Jan 2020 03:54
URI: http://eprints.um.edu.my/id/eprint/10497

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year