Awang, Khalijah and Mukhtar, Mat Ropi and Osman, Norfaizah and Hazni, Hazrina and Qureshi, Ahmad Kaleem and A. Hadi, A. Hamid and Zaima, Kazuma and Morita, Hiroshi and Litaudon, Marc (2012) Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae). Molecules, 17. pp. 267-274. ISSN 1420-3049, DOI doi: 10.3390/molecules17010267.
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Neonaucline,_a_new_indole_alkaloid_from_the_leaves_of_Ochreinauclea_maingayii_(Hook._f.)_Ridsd._(Rubiaceae).pdf - Published Version Download (120kB) |
Abstract
A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10-5 M.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia |
| Uncontrolled Keywords: | Ochreinauclea maingayii; Neonaucline; Nauledine; Cadamine; Rubiaceae; Alkaloid. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Suhaila Syakila Alby |
| Date Deposited: | 14 Oct 2014 02:36 |
| Last Modified: | 02 Sep 2021 04:25 |
| URI: | http://eprints.um.edu.my/id/eprint/10497 |
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