Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery

Awang, K. and Zaima, K. and Takeyama, Y. and Koga, I. and Saito, A. and Tamamoto, H. and Syed Abd. Azziz, S.S. and Mukhtar, M.R. and Hadi, A.H. and Morita, H. (2012) Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery. Journal of Natural Medicines, 66. pp. 421-427. ISSN 1340-3443

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Abstract

Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 μM), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 μM. The action of (-)-limacine (4) was deduced to be mediated through the increased release of NO from endothelial cells, and that of pecrassipine A (7) and backebergine (12) partly mediated by NO release. Further, the action of pecrassipine A (7) and backebergine (12) may be attributed to their inhibition of the voltage-dependent Ca(2+) channel and receptor-operated Ca(2+) channel.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia--- doi: 10.1007/s11418-011-0600-4
Uncontrolled Keywords: Popowia perakensis; Phaeanthus crassipetalus; Vasorelaxant effect; Rat aortic artery; Isoquinoline alkaloids.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 11 Nov 2014 04:19
Last Modified: 11 Nov 2014 04:19
URI: http://eprints.um.edu.my/id/eprint/10486

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