Cytotoxic prenylated acetophenone dimers from acronychia pedunculata

Awang, Khalijah and Kouloura, E. and Halabalaki, M. and Lallemand, M.C. and Nam, S. and Jove, R. and Litaudon, M. and Hadi, A.H. and Skaltsounis, A.L. (2012) Cytotoxic prenylated acetophenone dimers from acronychia pedunculata. Journal of Natural Products, 75. pp. 1270-1276. ISSN 0163-3864

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Abstract

Three new acetophenone dimers or Acronychia-type acetophenones, acropyrone (1), acropyranol A (2), and acropyranol B (3), were isolated from the trunk bark of Acronychia pedunculata and structurally characterized, together with four known acetophenone dimers, acrovestone (4), acrovestenol (5), acrofolione A (6), and acrofolione B (7), the acetophenone monomer acronyline (8), and four furoquinoline alkaloids. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated acetophenone dimers were evaluated against the DU145 prostate and A2058 melanoma human cancer cell lines as well as the NHDF normal cell line. Acrovestone (4) and acrovestenol (5) exhibited substantial cytotoxicity, with IC50 values of 0.38 and 2.8 μM against A2058 melanoma cells as well as 0.93 and 2.7 μM against DU145 prostate cancer cells, respectively.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya, 59100 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Acronychia; acetophenone dimers; Alkaloids
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 14 Oct 2014 02:55
Last Modified: 04 Jan 2019 01:06
URI: http://eprints.um.edu.my/id/eprint/10476

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