Awang, Khalijah and Mollataghi, A. and Coudiere, E. and Hadi, A.H.A. and Mukhtar, M.R. and Litaudon, M. and Ata, A. (2012) Anti-acetylcholinesterase, anti-α-glucosidase, anti-leishmanial and anti-fungal activities of chemical constituents of Beilschmiedia species. Fitoterapia, 83. pp. 298-302. ISSN 0367-326X, DOI https://doi.org/10.1016/j.fitote.2011.11.009.
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Abstract
Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid,N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia |
| Uncontrolled Keywords: | Beilschmiediaa alloiophylla; B. kunstleri; 2-Hydroxy-9-methoxyaporphine; Anti-acetylcholinesterase activity Anti-α-glucosidase activity; Anti-leishmanial activity. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Suhaila Syakila Alby |
| Date Deposited: | 15 Oct 2014 00:52 |
| Last Modified: | 08 Mar 2019 08:34 |
| URI: | http://eprints.um.edu.my/id/eprint/10453 |
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