Kam, T.S. and Tan, S.J. and Low, Y.Y. and Choo, Y.M. and Abdullah, Z. and Etoh, T. and Hayashi, M. and Komiyama, K. (2010) Strychnan and secoangustilobine A type alkaloids from alstonia spatulata. Revision of the C-20 configuration of scholaricine. Journal of Natural Products, 73. pp. 1891-1897. ISSN 0163-3864,
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Abstract
A total of 25 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia spatulata, of which five are new alkaloids of the strychnan type (alstolucines A-E, 1-5)and the other, a new alkaloid of the secoangustilobine A type(alstolobine A, 6). The structures of these alkaloids were established using NMR and MS analysis and, in the case of alstolucine B (2), also confirmed by X-ray diffraction analysis. A reinvestigation of the stereochemical assignment of scholaricine (13) by NMR and X-ray analyses indicated that the configuration at C-20 required revision. Alkaloids 1, 2, 6, 7, 9, 10, and 13 reversed multidrug resistance in vincristine-resistant KB cells.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, University of Malaya --- doi: 10.1021/np100552b |
| Uncontrolled Keywords: | Alkaloids; NMR; Alstonia spatulata; Alstolucine. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Suhaila Syakila Alby |
| Date Deposited: | 04 Nov 2014 06:31 |
| Last Modified: | 04 Nov 2014 06:31 |
| URI: | http://eprints.um.edu.my/id/eprint/10400 |
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