Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla

Kam, T.S. and Lim, S.H. and Tan, S.J. and Low, Y.Y. (2011) Lumutinines A−D, linearly fused macroline−macroline and macroline−sarpagine bisindoles from alstonia macrophylla. Journal of Natural Products, 74. pp. 2556-2562. ISSN 0163-3864, DOI https://doi.org/10.1021/np200730j.

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Abstract

Four new linearly fused bisindole alkaloids, lumutinines A−D (1−4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline−macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Alstonia; Lumutinine; NMR
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 01:51
Last Modified: 15 Oct 2014 01:51
URI: http://eprints.um.edu.my/id/eprint/10393

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