Development of an alkaloid–pyrone annulation: synthesis of pleiomaltinine

Kam, T.S. and Ziegler, R.E. and Tan, S.J. and Porco Jr., J.A. (2012) Development of an alkaloid–pyrone annulation: synthesis of pleiomaltinine. Angewandte Chemie International Edition, 51. pp. 9348-9351. ISSN 1433-7851

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Abstract

Methodology for the synthesis of alkaloid-pyrones using a novel pyrone annulation of β–carbolines and indoles with 3-siloxy-4-pyrones is reported. The approach has enabled semisynthesis of the unprecedented alkaloid-pyrone pleiomaltinine from the plant-derived indole-alkaloid pleiocarpamine.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Alkaloid; Pleiomaltinine; Pyrone; Natural product.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 01:56
Last Modified: 15 Oct 2014 01:56
URI: http://eprints.um.edu.my/id/eprint/10389

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