Serum leptin concentration in young diabetics

Ismail, I.S. and Wan Mohamad, W.B. and Wan Nazaimoon, W.M. and Letchuman, R. and Hew, F.L. and Pendek, R. and Singaraveloo, M. and Faridah, I. and Sheriff, I.H. and Khalid, B.A.K. (1999) Serum leptin concentration in young diabetics. Journal of the ASEAN Federation of Endocrine Societies, 17 (1). pp. 29-37. ISSN 0857-1074

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Abstract

The objective of the study was to examine the serum leptin level in young diabetics (age of onset of diabetes <40 years old) and to determine its relationship with gender, body mass index (IBM), waist-hip ratio (WHR), type of diabetes, fasting (CF) and glucagon-stimulated C-peptide (CG). A total of 219 Type 1 (97 males, 122 females) and 423 Type 2 (216 males, 207 females) patients were recruited for the study. Blood was drawn for assays of C-peptide, leptin and glycosylated haemoglobin (HbAIc) after an overnight fast, and at 6 minutes after intravenous infusion of 1 mg glucagon for CG levels. The BMI was significantly higher in Type 2 than Type 1 diabetics (26.0±0.3 versus 22.4±0.6 kg/m2, p= 0.001). Males with Type 1 and Type 2 diabetes had significantly higher WHR compared to females. However, the serum leptin concentration was significantly higher in female subjects regardless of the type of diabetes (11.4±0.7 versus 5.4±0.5 ng/ml for Type 1 and 13.1±0.6 versus 7.8±0.4 ng/ml for Type 2) and BMI (10.7±0.7 versus 4.0±0.8 ng/ml for Type 1 diabetics and 10.8±0.6 versus 5.8±0.5 ng/ml for Type 2 diabetics with BMI _<25 kg/m², 15.5±0.2 versus 6.9±l.4 ng/ml for Type 1 and 16.2±1.0 versus 9.9±0.2 ng/ml for Type 2 diabetics with BMI >25 kglm2). Leptin concentration was positively correlated with BMI (r=0.410, p=0.0001 for Type 1; r=0.416, p=0.0001 for Type 2). The best independent predictors for serum leptin were BMI (female), age (Type 2 only ), WHR (Type 1 males and females only), CF (males only) and CG. This study confirmed that besides gender, BMI, WHR and C-peptide levels are also important factors in predicting serum leptin concentration in diabetics.

Item Type: Article
Additional Information: Faculty of Medicine Universiti Malaya
Uncontrolled Keywords: Serum leptin; Young diabetics
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Izzan Ramizah Idris
Date Deposited: 31 Oct 2014 03:03
Last Modified: 31 Oct 2014 03:03
URI: http://eprints.um.edu.my/id/eprint/10369

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