Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia

Chuah, C.H. and Tan, H.P. and Wong, D.Z.H. and Ling, S.K. and Abdul Kadir, H. (2012) Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia. Fitoterapia, 83. pp. 223-229. ISSN 0367-326X

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Abstract

The galloylated cyanogenic glucosides based on prunasin (1–7), gallotannins (8–14), ellagitannins(15–17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya -------------doi:10.1016/j.fitote.2011.10.019
Uncontrolled Keywords: Phyllagathis rotundifolia; Galloylated cyanogenic glucosides Hydrolysable tannins; Neuroprotective; NG108-15 hybridoma cell line; H2O2.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 16 Oct 2014 02:28
Last Modified: 16 Oct 2014 02:30
URI: http://eprints.um.edu.my/id/eprint/10294

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