Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial

Chin, K.F. and Jayasimhan, S. and Yap, N.Y. and Roest, Y. and Rajandram, R. (2013) Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 32. pp. 928-934. ISSN 0261-5614

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Abstract

Background & aims: Probiotics is an emerging therapeutic agent which may alleviate the symptoms of constipation. We evaluated the effectiveness of microbial cell preparation (Hexbio®) containing fructooligosaccharide,Bifidobacterium and Lactobacillus in improving stool frequency and symptoms of chronic constipation. Methods: A total of 120 constipated adults diagnosed using Rome III criteria were randomized and given either microbial cell preparation or placebo to be consumed twice daily. Follow-up was done after a 7-day intervention based on a questionnaire which includes an assessment of symptom profile and a stool diary. Results: During the intervention period, the stool frequency was higher (p = 0.001) in the treatment group. Subjects experienced less straining (p = 0.001) and sensation of incomplete evacuation (p < 0.001), as well as improved stool consistency (p < 0.001) compared to the placebo group. While a higher proportion of subjects in the treatment group had a reduction in anorectal blockage sensation and having to defecate by manual maneuvers, the differences were not statistically significant.

Item Type: Article
Additional Information: Department of Surgery, Faculty of Medicine, University of Malaya
Uncontrolled Keywords: Chronic constipation; Microbial cell; Probiotics; Lactobacillus; Bifibobacterium.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 23 Oct 2014 08:34
Last Modified: 23 Oct 2014 08:34
URI: http://eprints.um.edu.my/id/eprint/10195

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