Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh

Leong, K.H. (2012) Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh. Molecules Online, 18 (1). pp. 128-139.

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Official URL: http://www.mdpi.com/1420-3049/18/1/128

Abstract

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.

Item Type: Article
Uncontrolled Keywords: Goniothalamus tapisoides; goniomicins A–D; tapisoidin; cytotoxicity; antioxidant activity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
R Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Medicine
Depositing User: Dr. Leong Kok Hoong
Date Deposited: 22 May 2014 02:08
Last Modified: 31 Jul 2018 04:25
URI: http://eprints.um.edu.my/id/eprint/10005

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